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The Application of Optical Coherence Tomography in Musculoskeletal Disease
Christopher Rashidifard,Christopher Vercollone,Scott Martin,Bin Liu
Arthritis , 2013, DOI: 10.1155/2013/563268
Abstract:
Comparison of artifact generation with catheter bending using different PS-OCT approaches
Kathy Zheng, Christopher Rashidifard, Bin Liu, Mark Brezinski
Reports in Medical Imaging , 2009, DOI: http://dx.doi.org/10.2147/RMI.S4389
Abstract: mparison of artifact generation with catheter bending using different PS-OCT approaches Original Research (5792) Total Article Views Authors: Kathy Zheng, Christopher Rashidifard, Bin Liu, Mark Brezinski Published Date May 2009 Volume 2009:2 Pages 49 - 54 DOI: http://dx.doi.org/10.2147/RMI.S4389 Kathy Zheng1, Christopher Rashidifard1, Bin Liu1,2, Mark Brezinski1,2 1Center for Optical Coherence Tomography and Optical Physics, Department of Orthopedic Surgery, Brigham and Women’s Hospital, Boston, MA, USA; 2Harvard Medical School, Boston, MA, USA Abstract: Optical coherence tomography (OCT) is a promising biomedical imaging tool for detecting pathology at a micron scale. In addition to performing structural imaging, other adjuvant techniques are available with OCT. In particular, polarization-sensitive optical coherence tomography (PS-OCT) can be used, either through a single or dual detector approach, to assess collagen concentration and organization. In this paper, we compare the ability of single and dual detector PS-OCT with respect to catheter bending artifacts. It was found that even severe catheter bending resulted in no significant difference in quantitative birefringence measurement with the single detector approach. However, when the dual detector approach was examined, catheter bending resulted in a highly significant change in backreflection intensity. This paper raises questions as to the appropriateness of dual detector PS-OCT for performing catheter and endoscope based birefringence assessments.
Comparison of artifact generation with catheter bending using different PS-OCT approaches
Kathy Zheng,Christopher Rashidifard,Bin Liu,Mark Brezinski
Reports in Medical Imaging , 2009,
Abstract: Kathy Zheng1, Christopher Rashidifard1, Bin Liu1,2, Mark Brezinski1,21Center for Optical Coherence Tomography and Optical Physics, Department of Orthopedic Surgery, Brigham and Women’s Hospital, Boston, MA, USA; 2Harvard Medical School, Boston, MA, USAAbstract: Optical coherence tomography (OCT) is a promising biomedical imaging tool for detecting pathology at a micron scale. In addition to performing structural imaging, other adjuvant techniques are available with OCT. In particular, polarization-sensitive optical coherence tomography (PS-OCT) can be used, either through a single or dual detector approach, to assess collagen concentration and organization. In this paper, we compare the ability of single and dual detector PS-OCT with respect to catheter bending artifacts. It was found that even severe catheter bending resulted in no significant difference in quantitative birefringence measurement with the single detector approach. However, when the dual detector approach was examined, catheter bending resulted in a highly significant change in backreflection intensity. This paper raises questions as to the appropriateness of dual detector PS-OCT for performing catheter and endoscope based birefringence assessments.Keywords: Optical coherence tomography, polarization, single detector, endoscopic imaging
The Application of Optical Coherence Tomography in Musculoskeletal Disease
Christopher Rashidifard,Christopher Vercollone,Scott Martin,Bin Liu,Mark E. Brezinski
Arthritis , 2013, DOI: 10.1155/2013/563268
Abstract: Many musculoskeletal disorders (MDs) are associated with irreversible bone and cartilage damage; this is particularly true for osteoarthritis (OA). Therefore, a clinical need exists for modalities which can detect OA and other MDs at early stages. Optical coherence tomography (OCT) is an infrared-based imaging, currently FDA approved in cardiology and ophthalmology, which has a resolution greater than 10 microns and acquisition rate of 120 frames/second. It has shown feasibility for imaging early OA, identifying changes prior to cartilage thinning both in vitro and in vivo in patients and in OA animal models. In addition, OCT has shown an ability to identify early rheumatoid arthritis (RA) and guide tendon repair, but has the potential for an even greater impact. Clinical trials in OA are currently underway, as well as in several other MDs. 1. Introduction Musculoskeletal diseases are one of the leading causes of disability in the United States. Fifty million adults in USA have been diagnosed with arthritis, rheumatoid arthritis, gout, systemic lupus erythematosus, or fibromyalgia, and approximately 1 in 3 people between ages 18 to 64 with diagnosed arthritis have work limitations [1, 2]. Similarly, disease of the periarticular structures, such as tendons and ligaments, contributes to additional disabilities and limitations. Full- or partial-thickness tears of rotator cuff tendons (RCT) are relatively common; they occur in approximately 30% of the population and represent around 4.5 million clinic visits and 40,000 surgeries in the USA per year [3]. Arthritis also affects the pediatric population, with an estimate 294,000 children under the age of 18, or 1 in every 250, having some form of arthritic or rheumatologic condition [4]. Studies estimate that by the year 2030, 67 million Americans older than 18 years will have doctor-diagnosed arthritis [5]. This paper examines the potential of the new micron-scale imaging technology and optical coherence tomography (OCT), for the management of musculoskeletal disease. It focuses on the existing clinical need for a high-resolution micron-scale imaging system in the field of orthopedics, including osteoarthritis (OA), rheumatoid arthritis (RA), and rotator cuff repair (RCR). However, this is far from the full extent of potential applications. Early detection of disease, understanding early disease markers, and accurate assessment of tissue microstructure are necessary to increase success of treatment, reduce patient morbidity, and determine the progress of future therapeutics in hopes of improving patient
What Role Can Propinquity Play in the Development of New National Allegiances? Immigrant Latinos Establishing Ties to the United States through Out-Group Contact  [PDF]
Christopher Olds
Advances in Applied Sociology (AASoci) , 2012, DOI: 10.4236/aasoci.2012.21002
Abstract: Contact theory has primarily been applied to the study of interactions between Blacks and Whites, with particular emphasis on changes in the attitudes of Whites towards Blacks. How individual contact with an out-group can influence not just attitudes, but also actual behavior, has not been thoroughly explored. Through an analysis of the 2006 Latino National Survey, using a measure that contrasts the intensity of individual social interaction with various ethnic and racial groups, the study shows that a high intensity of friendly social contact with African-Americans increases the likelihood Latino immigrants will establish a closer link to the social and political structures of the United States. Latino immigrants are potentially experiencing movement towards deprovincialization through high levels of friendly social interaction with African-Americans. The development of friendly personal interactions with an out-group stigmatized in the mother country can help Latino immigrants develop an optimistic view of life in the host country.
Net primary production and carbon cycling in coast redwood forests of central California  [PDF]
Christopher Potter
Open Journal of Ecology (OJE) , 2012, DOI: 10.4236/oje.2012.23018
Abstract: A simulation model to estimate net primary productivity (NPP) has been combined with in situ measurements of soil carbon dioxide (CO2) emissions and leaf litter pools in three coast redwood forest stands on the central California coast. Monthly NPP was predicted from the CASA model using 250-meter resolution vegetation index (VI) inputs. Annual NPP was predicted to vary from 380 g·C·m-2·yr-1 to 648 g·C·m-2·yr-1 at central coast redwood sites over the years 2007 to 2010. Measured soil respiration rates at between 0.5 to 2.2 g·C·m-2·d-1 were slightly below the range of measurements previously reported for a second-growth mixed (redwood and Douglas-fir) conifer forests. Although warm monthly temperatures at the southern-most redwood forest sites evidently results in elevated stress levels to sustained redwood growth into the dry summer months of June and July, these redwood stands appear to sequester CO2 from that atmosphere into forest biomass for a net positive ecosystem carbon balance each year.
Ten Years of Vegetation Change in Northern California Marshlands Detected Using Landsat Satellite Image Analysis  [PDF]
Christopher Potter
Journal of Water Resource and Protection (JWARP) , 2013, DOI: 10.4236/jwarp.2013.55048
Abstract:

The Landsat Ecosystem Disturbance Adaptive Processing System (LEDAPS) methodology was applied to detect changes in perennial vegetation cover at marshland sites in Northern California reported to have undergone restoration between 1999 and 2009. Results showed extensive contiguous areas of restored marshland plant cover at 10 of the 14 sites selected. Gains in either woody shrub cover and/or from a recovery of herbaceous cover that remains productive and evergreen on a year round basis could be mapped out from the image results. However, LEDAPS may not be highly sensitive changes in wetlands that have been restored mainly with seasonal herbaceous cover (e.g., vernal pools), due to the ephemeral nature of the plant greenness signal. Based on this evaluation, the LEDAPS methodology would be capable of fulfilling a pressing need for consistent, continual, low-cost monitoring of changes in marshland ecosystems of the Pacific Flyway.

Ex Post Efficient Set Mathematics  [PDF]
Christopher Adcock
Journal of Mathematical Finance (JMF) , 2013, DOI: 10.4236/jmf.2013.31A019
Abstract:

This paper considers efficient set mathematics for the case where the covariance matrix of asset returns is assumed known but ex ante the vector of expected returns is replaced by an estimated or forecast value. It is shown that the ex post mean and variance differ from the standard results. Consequently the maximum Sharpe ratio portfolio also differs from the standard result. However, even with uncertainty about the vector of expected returns, subject to the assumptions made about the joint distribution of actual returns and estimated mean returns, ex post Sharpe ratio maximisers hold the ex post market portfolio. The properties of the zero beta portfolio are similar to the standard results leading to a capital market line. The ex post Capital Asset Pricing Model incorporates an intercept and the betas are not the same as those computed ex ante. The results are illustrated with an example.

 

Mortality and motivations: Clinicians’ integrity engaging death within complex cultural context  [PDF]
Christopher Jenner
Open Journal of Nursing (OJN) , 2013, DOI: 10.4236/ojn.2013.31011
Abstract:

This broad ranging discussion examines the clinical encounter and deconstructs psychological and cultural context and implications, finally honoring the comprehensive awareness that the clinician requires for best practice in encountering mortality. Clinicians engage client disease and dying presentions, and ultimate mortality. Communicating mortality openly or subliminally is not always conscious. Mortality awareness can produce stress and untoward behaviors. Psychological mortality avoidance, citing Kierke-gaard’s existential paradox, and the death (in both senses) of Joseph Campbell’s cultural hero illumine socio-cultural elements including the elusive “good death”, sequestration of death from society, and the concept of managing death in volume. Cultural diversity awareness and the concept of transcendence clarify outlier and hybrid cultural client presentations demanding maximal clinician flexibility. Mortality Salience Theory predicts contracted world view when confronted with mortality, demanding sensitivity to a variety of responses. A hospice approach may not be best for some, despite a lack of new alternative to that paradigm. Managing mortality awareness and dying stresses the clinician by the weight and loneliness of perhaps unpopular decisions, by responsibility to community in managing death, and by the take-home exposure of the clinician’s family to the concept of death and mortality. Aptitude for managing death depends on clinician self awareness and a good match with practice venue. Clinician integrity and consciousness of motives and responses allows engagement or deferral as necessary without threat to identity.

Regional Analysis of NASA Satellite Greenness Trends for Ecosystems of Arctic Alaska  [PDF]
Christopher Potter
International Journal of Geosciences (IJG) , 2014, DOI: 10.4236/ijg.2014.59085
Abstract:

Trends in the growing season MODerate resolution Imaging Spectroradiometer (MODIS) Enhanced Vegetation Index (EVI) time-series were analyzed for the period from 2000 to 2010 to understand landscape-level patterns of vegetation change in ecosystems of arctic Alaska. We compared datasets for vegetation cover types, wetland cover classes, wildfire boundaries since the 1940s, permafrost type, and elevation to identify the most likely combination of factors driving regional changes in habitat quality and ecosystem productivity. Approximately 57% of all arctic ecosystem areas in Alaska were detected with significant (p < 0.05) positive or negative MODIS growing season EVI trends from 2000 to 2010. Nearly all (99%) of these ecosystem areas (covering 178,050 km2) were detected with significant positive growing season EVI trends. The vast majority of the arctic Alaska region detected with significant positive growing season EVI trends was classified as upland tundra cover, although non-forested wetlands (marshes, bogs, fens, and floodplains) were co-located on 8% of that area. Herbaceous wetlands were co-located on 55% of the total area detected with significant negative growing season EVI trends, mostly on the arctic coastal plain and foothills. This evidence supports the hypothesis that temperature (warming) has markedly enhanced the rates of upland tundra vegetation growth across most of arctic Alaska over recent years.

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